Chiral tubule self-assembly from an achiral diynoic lipid

S. Pakhomov, R. P. Hammer, B. K. Mishra, B. N. Thomas
2003 Proceedings of the National Academy of Sciences of the United States of America  
Tubules possessing m-scale chiral substructure self-assemble from an achiral isomer of the tubule-forming diynoic phosphatidylcholine, 1,2-bis(10,12-tricosadiynoyl)sn-glycero-3-phosphocholine [DC(8,9)PC], showing that molecular chirality is not essential for tubule formation. CD spectroscopy shows that these structures' helical sense of handedness instead originates in a spontaneous cooperative chiral symmetry-breaking process. We conclude that the chiral symmetry-breaking must originate in the
more » ... unusual feature common to the chiral and achiral tubule-forming molecules, the diynes centered in their hydrocarbon tails.
doi:10.1073/pnas.0030051100 pmid:12626752 pmcid:PMC152241 fatcat:vvwnj466ufhopb3btapmofyspu