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The evolution of enzyme function in the isomerases
2014
Current Opinion in Structural Biology
The advent of computational approaches to measure functional similarity between enzymes adds a new dimension to existing evolutionary studies based on sequence and structure. This paper reviews research efforts aiming to understand the evolution of enzyme function in superfamilies, presenting a novel strategy to provide an overview of the evolution of enzymes belonging to an individual EC class, using the isomerases as an exemplar. Corresponding authors: Martinez Cuesta, Sergio
doi:10.1016/j.sbi.2014.06.002
pmid:25000289
pmcid:PMC4139412
fatcat:jl366uxgrfchpdgknr5dl5pehm