The reluctant polymorph: investigation into the effect of self-association on the solvent mediated phase transformation and nucleation of theophylline

Raitis Bobrovs, Linda Seton, Nicola Dempster
2015 CrysteEngComm  
Evidence that theophylline forms aggregates in H-bond donor solvents, and the presence of these aggregates hinders the nucleation and phase transformation to form IV.
doi:10.1039/c4ce02484b fatcat:ktnu36lewbclvazmanp6umfirm