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Sildenafil attenuates hypoxic pulmonary remodelling by inhibiting bone marrow progenitor cells
2016
Journal of Cellular and Molecular Medicine
The recruitment of bone marrow (BM)-derived progenitor cells to the lung is related to pulmonary remodelling and the pathogenesis of pulmonary hypertension (PH). Although sildenafil is a known target in PH treatment, the underlying molecular mechanism is still elusive. To test the hypothesis that the therapeutic effect of sildenafil is linked to the reduced recruitment of BM-derived progenitor cells, we induced pulmonary remodelling in rats by two-week exposure to chronic hypoxia (CH, 10%
doi:10.1111/jcmm.13026
pmid:27860185
pmcid:PMC5387166
fatcat:sdeofwyo7vfmfnpqn73idumc5e