The present study aimed to formulate a mucoadhesive in situ gel with mucilage extracted from Corchorus olitorius for the intranasal route. Propranolol HCl used as a model drug. For the comparative study, the mucoadhesive in situ gels were prepared using two different concentration 0.4% and 0.5% of C. olitorius mucilage, Carbopol P-934 and hydroxypropyl methylcellulose. The prepared in situ gel was subjected to characterization test, such as pH, appearance, gelation temperature, spreadability,

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... scosity, mucoadhesive strength, and in vitro study. From the comparative study, 0.5% mucilage containing in situ gel formulation can be considered as optimum formulation.