Producer T cells: Using genetically engineered T cells as vehicles to generate and deliver therapeutics to tumors

Alexander K. Tsai, Eduardo Davila
<span title="2016-01-15">2016</span> <i title="Informa UK Limited"> <a target="_blank" rel="noopener" href="" style="color: black;">Oncoimmunology</a> </i> &nbsp;
Adoptive cell transfer (ACT) is an emerging anticancer therapy that has shown promise in various malignancies. Redirecting antigen specificity by genetically engineering T cells to stably express receptors has become an effective variant of ACT. A novel extension of this approach is to utilize engineered T cells to produce and deliver anticancer therapeutics that enhance cytotoxic T cell function and simultaneously inhibit immunosuppressive processes. Here, we review the potential of using T
more &raquo; ... ls as therapeuticsecreting vehicles for immunotherapies and present theoretical and established arguments in support of further development of this unique cell-based immunotherapy.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="">doi:10.1080/2162402x.2015.1122158</a> <a target="_blank" rel="external noopener" href="">pmid:27467930</a> <a target="_blank" rel="external noopener" href="">pmcid:PMC4910704</a> <a target="_blank" rel="external noopener" href="">fatcat:2iaiffcts5fzhdnvvy2ofmsqfu</a> </span>
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