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Producer T cells: Using genetically engineered T cells as vehicles to generate and deliver therapeutics to tumors
<span title="2016-01-15">2016</span>
<i title="Informa UK Limited">
<a target="_blank" rel="noopener" href="https://fatcat.wiki/container/mvghqzcikfdhlpmzpppdyowjue" style="color: black;">Oncoimmunology</a>
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Adoptive cell transfer (ACT) is an emerging anticancer therapy that has shown promise in various malignancies. Redirecting antigen specificity by genetically engineering T cells to stably express receptors has become an effective variant of ACT. A novel extension of this approach is to utilize engineered T cells to produce and deliver anticancer therapeutics that enhance cytotoxic T cell function and simultaneously inhibit immunosuppressive processes. Here, we review the potential of using T
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... ls as therapeuticsecreting vehicles for immunotherapies and present theoretical and established arguments in support of further development of this unique cell-based immunotherapy.
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