Effect of testosterone propionate on hippocampal pyramidal neuron number in female rats

M Candemir, S Semiz, GN Yonguc, MB Ozdemir, G Abban-Mete, E Adiguzel
2013 Singapore medical journal  
RESULTS Control male rats (Group 5; p = 0.043) and TP-treated female rats in Groups 1 (p = 0.012) and 2 (p = 0.037), but not Group 3 (p > 0.05), had a significantly higher number of pyramidal neurons than control female rats (Group 4). The rats in Group 1 had the highest number of pyramidal neurons among the female rats. CONCLUSION Perinatal TP treatment has an augmenting effect on the number of pyramidal neurons in the hippocampi of female rats. We also found gender-based differences in the
more » ... fferences in the hippocampi of male and female rats, with a higher number of pyramidal neurons seen in male rats. Continuous TP administration during the prenatal and postnatal periods is more effective than administration only in the prenatal or postnatal period.
doi:10.11622/smedj.2013124 pmid:23820541 fatcat:qzuisruae5fhtnfc7ao5bndpgq