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Translational Control by RNA-RNA Interaction: Improved Computation of RNA-RNA Binding Thermodynamics
[chapter]
Communications in Computer and Information Science
The thermodynamics of RNA-RNA interaction consists of two components: the energy necessary to make a potential binding region accessible, i.e. unpaired, and the energy gained from the base pairing of the two interaction partners. We show here that both components can be efficiently computed using an improved variant of RNAup. The method is then applied to a set of bacterial small RNAs involved in translational control. In all cases of biologically active sRNA target interactions, the target
doi:10.1007/978-3-540-70600-7_9
fatcat:wqnxtnnzmnfz5i7su2kbwekaiu