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Naturally occurring smallpox has been eradicated, yet it remains as one of the highest priority pathogens due to its potential as a biological weapon. The majority of the US population would be vulnerable in a smallpox outbreak. SIGA Technologies, Inc. has responded to the call of the US government to develop and supply to the Strategic National Stockpile a smallpox antiviral to be deployed in the event of a smallpox outbreak. ST-246 ® (tecovirimat) was initially identified via adoi:10.2217/fvl.11.27 pmid:21837250 pmcid:PMC3151656 fatcat:ah22dpco3nbq7la2b5tiuti4tu