Nowadays proton beam radiation therapy is considered in few centers for management of malignancies. This study is aimed to explore the effect of proton, helium or carbon irradiation on free radicals. This study was conducted in Bragg peak and for calculated the effect of proton, helium and carbon ions against free radicals related to oxygen, nitrogen and halogen species.The lowest stopping power near Bragg's peak of proton targeting free radicals was against superoxide anion and its curve (the

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... topping power against energy) was shifted down while that of peroxynitrite (ONOO-) was shifted up. The stopping powers of helium targeting all studied free radicals were lower than corresponding proton irradiation but it required higher energy. Lower stopping power of carbon irradiation targeted hydroxyl (OH-) and halogenated radicals than the other reactive species were observed. It concludes that such form of external beam irradiation is associated with direct scavenging effect on free radicals of whatever sources.