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Binding specificity of ASHH2 CW-domain towards H3K4me1 ligand is coupled to its structural stability through its α1-helix
[article]
2021
bioRxiv
pre-print
The CW domain binds to histone-tail modifications found in different protein families involved in epigenetic regulation and chromatin remodelling. CW domains recognize the methylation state of the fourth lysine on histone 3, and as such could be viewed as a reader of epigentic information. The specificity towards different methylation states such as me1, me2 or me3 depend on the particular subtype. For example, the CW domain of ASHH2-methyltransferase binds preferentially to H3K4me1, MORC3
doi:10.1101/2021.08.12.456084
fatcat:bive5iywdfdbfehlore3iqvbtu