Differential conductance as a promising approach for rapid DNA sequencing with nanopore-embedded electrodes

Yuhui He, Lubing Shao, Ralph H. Scheicher, Anton Grigoriev, Rajeev Ahuja, Shibing Long, Zhuoyu Ji, Zhaoan Yu, Ming Liu
2010 Applied Physics Letters  
We propose an approach for nanopore-based DNA sequencing using characteristic transverse differential conductance. Molecular dynamics and electron transport simulations show that the transverse differential conductance during the translocation of DNA through the nanopore is distinguishable enough for the detection of the base sequence and can withstand electrical noise caused by DNA structure fluctuation. Our findings demonstrate several advantages of the transverse conductance approach, which
more » ... ce approach, which may lead to important applications in rapid genome sequencing.
doi:10.1063/1.3467194 fatcat:jh2uyfl33ncl5jju4fymgfeqwq