The Effects of ERCC1 Expression Levels on the Chemo-resistance of Breast Cancer Patients Treated with Platinum-based Adjuvant Chemotherapy

Suhad Karim, A Al Majeed, Mohammad Nader
2017 Iraqi Journal of Biotechnology   unpublished
Excision repair cross-complementing 1 (ercc1) is reported to be involved in the sensitivity of cancer patients to platinum-based chemotherapy. The present study to evaluate the effects of ERCC1 expression on the chemosensitivity of platinum agents in breast cancer. ercc1 expression levels were measured by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). The results demonstrated patients with low ercc1 levels had chemosensitive than those with high ercc1 levels. These
more » ... levels. These results suggest that overexpression of ercc1 is correlated with platinum drug resistance in breast cancer patients .The patients with low levels of ercc1 expression demonstrate a benefit from platinum-based adjuvant chemotherapy.