Nasopharyngeal carcinoma (NPC) is a tumor arising from the epithelial cells lining the nasopharynx. The development of a second primary tumor in subjects with a previous history of nasopharyngeal carcinoma is a rare event. The most common second primary cancer which can occur is sarcoma (0.14%), followed by leukemia and squamous cell carcinoma. In the present case, a second primary tumor (squamous cell carcinoma) on right lateral border of tongue in a 64 year old male patient treated for

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... ryngeal carcinoma with radiotherapy and chemotherapy 5 years previously is discussed. Copy Right, IJAR, 2017,. All rights reserved. ...................................................................................................................... Introduction:- Nasopharyngeal carcinoma (NPC) is a tumor arising from the epithelial cells lining the nasopharynx. 1 The development of a second primary malignant tumor in subjects with a previous history of nasopharyngeal carcinoma is unusual. 2 The most common second primary cancer which can occur is sarcoma (0.14%), followed by leukemia and squamous cell carcinoma. 2 These second primaries can occur in the lung, oesophagus and also in the head and neck region. 2 In the oro-pharyngeal region, tongue is a common site of involvement (1.8%). 2 The proposed pathogenic mechanisms of the development of second primary cancers include radiotherapy, field cancerization and common risk factors. 2 The present case is of second primary tumor (squamous cell carcinoma) on right lateral border of tongue in a 64 year old male patient treated for nasopharyngeal carcinoma. Case Report:- A 64 year old male visited the department of Oral medicine and Radiology with a complaint of frequent biting of the right side of the tongue while eating and talking since 6 months. He had visited several dental practitioners for the management of the same and coronoplasty of maxillary and mandibular posterior teeth was performed. However, there was no relief. He had visited an oncology centre 2 days prior to visiting the present institution for a PET-CT scan. The scan was advised as a part of the follow-up protocol for treated nasopharyngeal carcinoma that was diagnosed 5 years ago. Patient had undergone radiotherapy and chemotherapy for the same. The treatment was completed 4 years ago. An increased FDG uptake was noted on PET-CT with regard to the right lateral aspect of tongue. He was advised partial glossectomy by the oncosurgeon for the same.