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IMMU-01. CYTOTOXIC AND SUPPRESSIVE IMMUNE CELL TRAFFICKING TO PEDIATRIC BRAIN TUMORS: A BALANCING ACT
2017
Neuro-Oncology
Abstracts iv27 NEURO-ONCOLOGY • JUNE 2017 and CHI3L1. We observed a marked increase in the invasive capacity of pHGG and DIPG patient-derived cultures upon the addition of active CM in both transwell and three-dimensional (3D) in vitro invasion assays. Analysis of several candidate proteins identified via proteomic screens highlighted two secreted factors, GRP78 and CRTAC1, which alone were sufficient to increase pHGG invasion. Abrogation of this pro-infiltrative effect was seen upon
doi:10.1093/neuonc/nox083.112
fatcat:qofy3buaqzbf7bwt2wghdhdboe