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The paper presents a summary of the Olle Höök lecture, which was presented at the Baltic North-Sea Forum in Oslo, Sweden, in October 2019. The paper aims to provide a worldwide picture of stroke, developments in this field, and the evolution of stroke rehabilitation. It sets out the background to, evidence for, and content of the comprehensive stroke unit. The paper also describes some rehabilitation techniques based on neurophysiology, the use of robotics, and the evidence level fordoi:10.2340/16501977-2670 pmid:32296853 fatcat:pdtf6l7bpra4xifnju2zfrwwzi