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Nitrite is a positive modulator of the Frank-Starling response in the vertebrate heart
American Journal of Physiology. Regulatory Integrative and Comparative Physiology
Evidence from both mammalian and nonmammalian vertebrates indicates that intracardiac nitric oxide (NO) facilitates myocardial relaxation, ventricular diastolic distensibility, and, consequently, the Frank-Starling response, i.e., the preload-induced increase of cardiac output. Since nitrite ion (NO 2 Ϫ ), the major storage pool of bioactive NO, recently emerged as a cardioprotective endogenous modulator, we explored its influence on the Frank-Starling response in eel, frog, and rat hearts,doi:10.1152/ajpregu.00616.2011 pmid:22492815 fatcat:7gejonxisrh33al75eczu7y2ya