Study of mucormycosis patients attending tertiary care hospital: a retrospective study

Amandeep Ludhar, Sachin S. Nilakhe
2019 International Journal of Research in Medical Sciences  
Treatment of mucormycosis involves a combination of surgical debridement of involved tissues and antifungal therapy. Intravenous amphotericin B is the drug of choice. In this study authors assessed the outcomes of treating patients with mucormycosis with varied formulations of amphotericin.Methods: Authors performed a retrospective observational study of patients diagnosed with mucormycosis and admitted in the inpatient ward of Bharati Hospital, Sangli, Maharashtra, India from May 2015 till May
more » ... 2018. Patients either received amphotericin B, lyophilized amphotericin B or lipid soluble amphotericin B. Resolution of symptoms was graded as good clinical response and persistence of symptoms as poor clinical response.Results: During the study period a total of 16 patients were included in the study. All patients underwent surgical debridement and received different forms of amphotericin. Three patients received amphotericin B 1.5 to 3 grams over 21 days and responded satisfactory and later had renal toxicity. Five patients received lyophilized amphotericin B 3 to 4 grams over 21 days, with good response and less renal toxicity as compared to amphotericin B. Lipid soluble amphotericin B was given to 8 patients 3.5 to 5 gm over 21 days with good clinical response and minimal renal toxicity. Of the 10 patients who presented with nasal discharge, 60% had a good clinical outcome, 30% had poor and one patient died.Conclusions: Amphotericin B is an effective anti-fungal. Further studies are needed to assess the utility of immunologic and metabolomic profiling of the host and prescribing targeted immunotherapy in decreasing the incidence of mucormycosis.
doi:10.18203/2320-6012.ijrms20191648 fatcat:ygol22g7crf7jo6rc4hsd6k7f4