Aim: This study aimed to discuss the association between BIRC5-625G/C polymorphism and hepatocel-lular carcinoma (HCC) susceptibility in south of China. Methods: We detected BIRC5-625G/C polymorphism in 106 HCC patients and 124 healthy persons in southern China and genotypes were separated with the method of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The correlation between BIRC5-625G/C polymorphism and HCC risk was evaluated by odds ratio (OR) with 95%

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... ence interval (CI) calculated using the chi-squared text. The genotypes distribution of BIRC5-625G/C in controls was checked based on Hardy-Weinberg equilibrium (HWE). Results: According to the data, we found that distributions of genotype CC and allele C in case group were higher than the control group, and the BIRC5-625G/C polymorphism could increase the HCC risk (CC vs. GG: OR=3.059, 95% CI=1.090-8.583; C vs. G: OR=1.547, 95% CI=1.025-2.335). HBsAg was associated with HCC risk and might make woke through the interaction with patients BIRC5-625G/C polymorphism (P=0.028). Conclusion: BIRC5-625G/C polymorphism might be an independent risk factor for the development of HCC and HBsAg is also associated with HCC.