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Development of Cu(ii)-specific peptide shuttles capable of preventing Cu–amyloid beta toxicity and importing bioavailable Cu into cells
2022
Chemical Science
Preserved Fulltext
The synthetic peptide AKH-αR5W4NBD was designed as a shuttle to counteract copper imbalance in Alzheimer's disease. In vitro, this shuttle is able to abstract Cu(ii) selectively from amyloid-β and transport it into cells in a bioavailable form.
doi:10.1039/d2sc02593k
fatcat:nw2yoazi3zgcnl24qpc6xct4w4