Development of Cu(ii)-specific peptide shuttles capable of preventing Cu–amyloid beta toxicity and importing bioavailable Cu into cells

Michael Okafor, Paulina Gonzalez, Pascale Ronot, Islah El Masoudi, Anne Boos, Stéphane Ory, Sylvette Chasserot-Golaz, Stéphane Gasman, Laurent Raibaut, Christelle Hureau, Nicolas Vitale, Peter Faller
2022 Chemical Science  
The synthetic peptide AKH-αR5W4NBD was designed as a shuttle to counteract copper imbalance in Alzheimer's disease. In vitro, this shuttle is able to abstract Cu(ii) selectively from amyloid-β and transport it into cells in a bioavailable form.
doi:10.1039/d2sc02593k fatcat:nw2yoazi3zgcnl24qpc6xct4w4