Beta2-Microglobulin Can Be a Disease Activity Marker in Systemic Lupus Erythematosus

Hyoun-Ah Kim, Ja-Young Jeon, Jeong-Moon Yoon, Chang-Hee Suh
2010 American Journal of the Medical Sciences  
To investigate the clinical significance of beta2-microglobulin in Korean patients with systemic lupus erythematosus (SLE). Methods: Blood samples were collected from patients with SLE (n ϭ 100) and normal healthy controls (n ϭ 50). The level of beta2-microglobulin was investigated by enzyme-linked immunosorbent assay. Serial samples from SLE patients were collected at 4.2 Ϯ 2.6 months after first sampling. Results: The beta2-microglobulin levels of the SLE patients (2.64 Ϯ 0.11 g/mL) were
more » ... r than the normal controls (2.14 Ϯ 0.04 g/mL, P Ͻ 0.001). The patients with SLE with serositis, oral ulcer, or lupus nephritis had significantly higher beta2-microglobulin levels than those without, respectively. A significant correlation was found between the beta2-microglobulin level and each of anti-dsDNA antibody, hemoglobin, complement, and SLE Disease Activity Index. In sequential sampling of patients with SLE, a positive correlation was found between the change of the SLE Disease Activity Index and the change of the beta2-microglobulin levels. Conclusions: These data suggest that the measurement of beta2-microglobulin seem to be a useful addition to the laboratory tests that can help in assessment of disease activity of SLE.
doi:10.1097/maj.0b013e3181d26dfb pmid:20186038 fatcat:r3dx6fuy2ze2flc7cw2b6sy3cq