EndoNet: an information resource about endocrine networks

A. Potapov
2006 Nucleic Acids Research  
EndoNet is a new database that provides information 10 about the components of endocrine networks and their relations. It focuses on the endocrine cellto-cell communication and enables the analysis of intercellular regulatory pathways in humans. In the EndoNet data model, two classes of components 15 span a bipartite directed graph. One class represents the hormones (in the broadest sense) secreted by defined donor cells. The other class consists of the acceptor or target cells expressing the
more » ... rresponding hormone receptors. The identity and anatomical 20 environment of cell types, tissues and organs is defined through references to the CYTOMER â ontology. With the EndoNet user interface, it is possible to query the database for hormones, receptors or tissues and to combine several items from different 25 search rounds in one complex result set, from which a network can be reconstructed and visualized. For each entity, a detailed characteristics page is available. Some well-established endocrine pathways are offered as showcases in the form of predefined 30 result sets. These sets can be used as a starting point for a more complex query or for obtaining a quick overview. The EndoNet database is accessible at
doi:10.1093/nar/gkj121 pmid:16381928 pmcid:PMC1347483 fatcat:7bn4ixyzl5a6hjhjspnvrdqfqa