Predicting specificity in bZIP coiled-coil protein interactions

Jessica H Fong, Amy E Keating, Mona Singh
2004 Genome Biology  
We present a method for predicting protein-protein interactions mediated by the coiled-coil motif. When tested on interactions between nearly all human and yeast bZIP proteins, our method identifies 70% of strong interactions while maintaining that 92% of predictions are correct. Furthermore, cross-validation testing shows that including the bZIP experimental data significantly improves performance. Our method can be used to predict bZIP interactions in other genomes and is a promising approach
more » ... for predicting coiled-coil interactions more generally.
doi:10.1186/gb-2004-5-2-r11 pmid:14759261 pmcid:PMC395749 fatcat:ydx2gvhlmbcthayqkbxqskxh74