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Predicting specificity in bZIP coiled-coil protein interactions
2004
Genome Biology
We present a method for predicting protein-protein interactions mediated by the coiled-coil motif. When tested on interactions between nearly all human and yeast bZIP proteins, our method identifies 70% of strong interactions while maintaining that 92% of predictions are correct. Furthermore, cross-validation testing shows that including the bZIP experimental data significantly improves performance. Our method can be used to predict bZIP interactions in other genomes and is a promising approach
doi:10.1186/gb-2004-5-2-r11
pmid:14759261
pmcid:PMC395749
fatcat:ydx2gvhlmbcthayqkbxqskxh74