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Efficiency of Xist-mediated silencing on autosomes is linked to chromosomal domain organisation
2010
Epigenetics & Chromatin
X chromosome inactivation, the mechanism used by mammals to equalise dosage of X-linked genes in XX females relative to XY males, is triggered by chromosome-wide localisation of a cis-acting non-coding RNA, Xist. The mechanism of Xist RNA spreading and Xist-dependent silencing is poorly understood. A large body of evidence indicates that silencing is more efficient on the X chromosome than on autosomes, leading to the idea that the X chromosome has acquired sequences that facilitate propagation
doi:10.1186/1756-8935-3-10
pmid:20459652
pmcid:PMC2873326
fatcat:txucmeehcrfnnjq67v5hgi4lqm