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Objective. Estimate the contribution of monocytes/macrophages to the disease process in rheumatoid arthritis (RA), by measuring the serum levels of the leucocyte-derived granular proteins: lysozyme, myeloperoxidase (MPO), lactoferrin and human neutrophil lipocalin (HNL). Methods. Serum levels of these granular proteins were measured in patients with RA (n = 23) and in healthy controls (n = 27), and in 10 patients with RA after treatment with lowdose prednisolone. The serum levels of thedoi:10.1093/rheumatology/38.12.1249 pmid:10587554 fatcat:bkgk2o2v35bzbkl3mql63pce6e