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A dual-receptor mechanism between integrins and ACE2 widens SARS-CoV-2 tissue tropism [article]

Danielle Nader, Timothy E Gressett, Md Lokman Hossen, Prem P Chapagain, Steven W. Kerrigan, Gregory Bix
2022 bioRxiv   pre-print

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In addition to the ACE2 receptor, SARS-CoV-2 binds to integrins to gain host cell entry and trigger pro-inflammatory integrin-mediated signalling cascades. Integrins, therefore, are likely candidates for a dual-receptor mechanism with ACE2 to explain the increased infectivity seen in SARS-CoV-2 models. As integrins are primarily expressed in vasculature and persistent vasculopathy is seen in COVID-19, examining the role of endothelial integrin involvement is crucial in uncovering the pathophysiology of SARS-CoV-2.
doi:10.1101/2022.01.02.474028 fatcat:b6ivklmtsjgcjenmpiw3rjzeta
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Danielle Nader, Timothy E Gressett, Md Lokman Hossen, Prem P Chapagain, Steven W. Kerrigan, Gregory Bix. "A dual-receptor mechanism between integrins and ACE2 widens SARS-CoV-2 tissue tropism." bioRxiv (2022)