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Design and syntheses of some new 5-[benzenesulphonamido]-1,3,4- thiadiazol-2-sulphonamide as potent antiepileptic agent
2013
Macroheterocycles
A QSAR study was performed on sulphonamide-1,3,4-thiadiazole derivatives using modified version of Allinger MM 2 force field in Chem 3D Ultra structural descriptors. The relationship between antiepileptic activity and various descriptors was established by stepwise multiple regression analysis. The analyses have produced well predictive and statistically significant QSAR models which were further cross validated. This study helps to design and to synthesize some expectedly potent compounds. )
doi:10.6060/mhc130116c
fatcat:sqt3qx6sojhzzebuzfcuwushuu