A damaged genome's transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks

Fabio Iannelli, Alessandro Galbiati, Ilaria Capozzo, Quan Nguyen, Brian Magnuson, Flavia Michelini, Giuseppina D'Alessandro, Matteo Cabrini, Marco Roncador, Sofia Francia, Nicola Crosetto, Mats Ljungman (+2 others)
2017 Nature Communications  
Supplementary Figure 2. (a) Number of predicted AsiSI sites upon in silico digestion of the GRCh37/hg19 human genome assembly. The number of sites has been normalized by the length of each chromosome. (b) Top-ranked AsiSI-induced cleavage site. The AsiSI recognition site with the highest γH2AX rank score is depicted. The panel represents a 20-fold zoom out, centered on the ~100 Kb window across which individual z-scores were averaged to calculate the score. The LOESS curves represent average
more » ... cores. Absence of dots indicates that no positive z-scores were calculated for the respective windows (no or negative enrichment over background). Supplementary Figure 3. (a) Venn diagram plot showing intersection of the 214 sites detected by BLISS (blue) and the 100 top sites detected according to γH2AX ChIP-seq (red).
doi:10.1038/ncomms15656 pmid:28561034 pmcid:PMC5499205 fatcat:c26g4xveabdl5ny45h7q5c7sd4