Heterocyclic Chemistry

2009 Chemistry International  
The palladium-catalyzed substitution reactions forming carbon-carbon and carbon-element bonds, as well as nickel-catalyzed addition of E-H and E-E′ bonds across multiple bonds, are considered in their application to the chemistry of heterocyclic compounds. FORMATION OF CARBON-CARBON BONDS We were the first to carry out the cross-coupling reactions of organomercury compounds with Ar(Het)X [1,2]. These reactions required the presence not only of the Pd-catalyst, but also a nucleophilic
more » ... eophilic catalyst-the iodide anion. Under protective argon atmosphere they gave high yields of the cross-coupling products. Many of the organomercury compounds were obtained by direct mercuration of aromatic substrate in situ. The organomercury compounds can themselves belong to hetorocyclic series. It is important that all the organic moieties of the organomercury compound are utilized in the reaction.
doi:10.1515/ci.2009.31.6.29 fatcat:qxypjrtgvbbljho7enoo6qs5fe