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UK-37,248, A Novel, Selective Thromboxane Synthetase Inhibitor With Anti-Aggregatory And Anti-Thrombotic Activity
1981
Thrombosis and Haemostasis
UK-37,248, 4-(2-(lH-imidazol-l-yl)ethoxy)benzoic acid hydrochloride, potently inhibited human blood platelet microsomal thronfooxane (Tx) synthetase, IC50=3xl0-9M. TxB2 was quantitated by a specific radioimmunoassay (RIA). In contrast (PG) endoperoxide synthesis by ram seminal vesicle microsomes and prostacylclin (PGI2) synthesis by pig aortic microsomes/were minimally affected by concentrations of UK-37,248 up to 1x10-4M. In the rabbit isolated perfused lung arachidonic acid (AA) metabolites
doi:10.1055/s-0038-1652828
fatcat:kgzfv5dnina7becuc7rqd6tvpi