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The present study was conducted to investigate the effect of different polymers on the release profile and bio-adhesive strength of a water soluble drug, ciprofloxacin HCl from different percentages of Eudragit RS PO and Kollidon SR based co-matrix tablets. Matrix formulations were prepared by direct compression method. The bioadhesive property was investigated in terms of retention time following in vitro wash-off method. The concentrations of polymers were varied to investigate whether thesedoi:10.3329/dujps.v9i2.7893 fatcat:uda2ewg7c5gb7cd3a4cptvjy7m