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Impact of alcohol on hepatic mitochondrial DNA damage in streptozotocin diabetic rats
Journal of Experimental and Applied Animal Sciences
Mitochondrial dysfunction with increased production of reactive oxygen species (ROS) is a characteristic feature of diabetes which is associated with damage of mitochondrial DNA (mtDNA). Alcohol metabolism generates ROS with enhanced oxidative stress leading to damage of cellular constituents including mtDNA. The aim of the present study is to investigate the impact of alcohol consumption on hepatic mtDNA damage in diabetic rats. MtDNA was isolated from hepatic tissues of non-diabetic anddoi:10.20454/jeaas.2017.1225 fatcat:v2i5fvzhsng7pppjvpowwleiba