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Fibronectin-Based Nanomechanical Biosensors to Map 3D Strains in Live Cells and Tissues
[article]
2020
bioRxiv
pre-print
Mechanical forces are integral to a wide range of cellular processes including migration, differentiation and tissue morphogenesis; however, it has proved challenging to directly measure strain at high spatial resolution and with minimal tissue perturbation. Here, we fabricated, calibrated, and tested a fibronectin (FN)-based nanomechanical biosensor (NMBS) that can be applied to cells and tissues to measure the magnitude, direction, and dynamics of strain from subcellular to tissue
doi:10.1101/2020.02.11.943696
fatcat:77fhxqovuzbcjo42r7stfesac4