In-vitro photobactericidal activity of aminoacridines

M. Wainwright, D. A. Phoenix, J. Marland, D. R. Wareing, F. J. Bolton
1997 Journal of Antimicrobial Chemotherapy  
The toxicities of several aminoacridines were measured against pathogenic strains of both Gram-positive (Staphylococcus aureus, Enterococcus faecalis, Bacillus cereus) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa) organisms. In several cases, illumination at a light dose of 6.3 J/cm 2 resulted in considerable decreases in the minimum lethal drug concentrations required, giving up to 50-fold increases in bactericidal activity. Derivatives of 9-aminoacridine (aminacrine) exhibited
more » ... hototoxicity against one or more of the test organisms, but the established photosensitizing acridines proflavine and acridine orange were photobactericidal against all strains.
doi:10.1093/jac/40.4.587 pmid:9372431 fatcat:6r73lvg3ezcubbjtqsjgnnos3q