Histopathological Findings In The Prostatic Urethra Evaluated By A New Technique For Processing Radical Prostatectomy Specimens
Radical prostatectomy is one of the common therapeutic options for the treatment of localized prostate cancer. The pathologic evaluation usually does not focus on the involvement of the prostatic urethra and periurethral area, and the cutting techniques commonly employed do not permit thorough evaluation of this region. Thus, pathologists' familiarity with the pathologic processes in this region is limited. Objectives: Our first objective was to describe and evaluate a new technique for
... g radical prostatectomy specimens, a technique which preserves the verumontanum and the prostatic urethra. Moreover, a thorough evaluation and description of the pathologic processes in this region was performed. Methods: Fifty radical prostatectomy specimens were evaluated. The prostate tissue underwent the continuous pressure of standard indwelling catheters during few hours. The specimens were processed and cut into six parts, consequently preserving the prostatic urethra in the middle posterior part. Total sampling of the prostatic gland was performed with thorough examination of the specimens focusing on the periurethral area and the pathologic findings, malignant and benign, were documented. Results: The technique described was successfully employed on all the examined specimens, allowing the standard staging and grading of the prostatic cancer, and permitting an excellent examination of the periurethral region. This new technique is simple to perform, and can be utilized in any pathology department. In 20 percent of the specimens the periurethral region was infiltrated by the adenocarcinoma. Additionally, a large number of various pathological findings in the prostatic urethra and verumontanum were recorded. The prostate area under the direct pressure of the catheter contained many atrophic areas with elongated glands. CONEXIUNI MEDICALE NUMĂRUL 1 (17) MARTIE 2010 9 ORIGINAL ARTICLES ARTICOLE ORIGINALE the periurethral area is preserved allows a better evaluation of this anatomic region. It is possible that further employment of this technique will spread light on pathological processes that might have clinical importance.