Ureteral Calculi Associated with High-Altitude Polycythemia: A Case Report and Literature Review [post]

Min Yang, Tanna Wuren, Kexiong Ma, Ri-Li Ge, Linhua Ji, Sen Cui
2020 unpublished
Background: High-altitude polycythemia (HAPC) is a common disease in high-altitude areas characterized by excessive erythrocyte proliferation and severe hypoxemia. Recently, the incidence of ureteral calculi has a rising trend. However, cases of ureteral calculi associated with high-altitude polycythemia have not been reported. Case Presentation: We present the cases of two patients with HAPC who were born in the lowlands and worked in high altitudes and were admitted to the hospital with acute
more » ... hospital with acute severe pain in the ureter as the first symptom. Urological examinations confirmed the presence of a ureteral stone. Interestingly, the biochemical tests showed elevated serum uric acid levels and the calculous component analysis suggested anhydrous uric acid. Recently, extensive research has demonstrated a significant correlation between hyperuricemia and high-altitude polycythemia. Therefore, we speculated that the occurrence of ureteral calculi among immigrants to the plateau might be related to hyperuricemia associated with high-altitude polycythemia. Conclusions: This case report and literature review highlights that the prevention of ureteral calculi in patients with polycythemia who immigrate to the plateaus from high-altitude areas should be considered. Additionally, the serum uric acid levels and urine pH should be monitored regularly.
doi:10.21203/rs.3.rs-87058/v1 fatcat:rtnjvwqmejbfrk527desxho6bu