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Progressive reconfiguration of resting-state brain networks as psychosis develops: Preliminary results from the North American Prodrome Longitudinal Study (NAPLS) consortium [article]

Hengyi Cao, Yoonho Chung, Sarah McEwen, Carrie Bearden, Jean Addington, Bradley Goodyear, Kristin Cadenhead, Heline Mirzakhanian, Barbara Cornblatt, Doreen Olvet, Daniel Mathalon, Thomas McGlashan (+11 others)
2017 bioRxiv   pre-print

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Mounting evidence has shown disrupted brain network architecture across the psychosis spectrum. However, whether these changes relate to the development of psychosis is unclear. Here, we used graph theoretical analysis to investigate longitudinal changes in resting-state brain networks in samples of 72 subjects at clinical high risk (including 8 cases who converted to full psychosis) and 48 healthy controls drawn from the North American Prodrome Longitudinal Study (NAPLS) consortium. We
more » ... progressive reduction in global efficiency (P = 0.006) and increase in network diversity (P = 0.001) in converters compared with non-converters and controls. More refined analysis separating nodes into nine key brain networks demonstrated that these alterations were primarily driven by progressively diminished local efficiency in the default-mode network (P = 0.004) and progressively enhanced node diversity across all networks (P < 0.05). The change rates of network efficiency and network diversity were significantly correlated (P = 0.003), suggesting these changes may reflect shared underlying neural mechanisms. In addition, change rates of global efficiency and node diversity were significantly correlated with change rate of cortical thinning in the prefrontal cortex in converters (P < 0.03) and could be predicted by visuospatial memory scores at baseline (P < 0.04). These results provide preliminary evidence for longitudinal reconfiguration of resting-state brain networks during psychosis development and suggest that decreased network efficiency, reflecting an increase in path length between nodes, and increased network diversity, reflecting a decrease in the consistency of functional network organization, are implicated in the progression to full psychosis.
doi:10.1101/179242 fatcat:2bpigycymvhwpfzyykpdv4inn4
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Hengyi Cao, Yoonho Chung, Sarah McEwen, Carrie Bearden, Jean Addington, Bradley Goodyear, Kristin Cadenhead, Heline Mirzakhanian, Barbara Cornblatt, Doreen Olvet, Daniel Mathalon, Thomas McGlashan, Diana Perkins, Aysenil Belger, Larry Seidman, Heidi Thermenos, Ming Tsuang, Theo van Erp, Elaine Walker, Stephan Hamann, Alan Anticevic, Scott Woods, Tyrone Cannon. "Progressive reconfiguration of resting-state brain networks as psychosis develops: Preliminary results from the North American Prodrome Longitudinal Study (NAPLS) consortium." bioRxiv (2017)