Intrahepatic Islet Transplantation in Type 1 Diabetic Patients Does Not Restore Hypoglycemic Hormonal Counterregulation or Symptom Recognition After Insulin Independence

B. W. Paty, E. A. Ryan, A.M. J. Shapiro, J. R.T. Lakey, R. P. Robertson
2002 Diabetes  
Islet allotransplantation can provide prolonged insulin independence in selected individuals with type 1 diabetes. Whether islet transplantation also restores hypoglycemic counterregulation is unclear. To determine if hypoglycemic counterregulation is restored by islet transplantation, we studied hormone responses and hypoglycemic symptom recognition in seven insulinindependent islet transplant recipients using a 3-h stepped hypoglycemic clamp, and compared their responses to those of
more » ... those of nontransplanted type 1 diabetic subjects and nondiabetic control subjects. Glucagon responses of islet transplant recipients to hypoglycemia were significantly less than that observed in control subjects (incremental glucagon [mean ؎ SE]: ؊12 ؎ 12 vs. 64 ؎ 22 pg/ml, respectively; P < 0.05), and not significantly different from that of nontransplanted type 1 diabetic subjects (؊17 ؎ 10 pg/ml). Epinephrine responses and symptom recognition were also not restored by islet transplantation ( incremental epinephrine [mean ؎ SE]: 195 ؎ 128 [islet transplant recipients] vs. 238 ؎ 73 [type 1 diabetic subjects] vs. 633 ؎ 139 pg/ml [nondiabetic control subjects], P < 0.05 vs. control; peak symptom scores: 3.3 ؎ 0.9 [islet transplant recipients] vs. 3.1 ؎ 1.1 [type 1 diabetic subjects] vs. 6.7 ؎ 0.8 [nondiabetic control subjects]) . Thus the results indicate that despite providing prolonged insulin independence and near-normal glycemic control in these patients with long-standing type 1 diabetes, hypoglycemic hormonal counterregulation and symptom recognition were not restored by intrahepatic islet transplantation.
doi:10.2337/diabetes.51.12.3428 pmid:12453896 fatcat:vafdnw74nbed3ij4uhwdfrgsbu