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Cytoskeletal Signaling: Is Memory Encoded in Microtubule Lattices by CaMKII Phosphorylation?
2012
PLoS Computational Biology
Memory is attributed to strengthened synaptic connections among particular brain neurons, yet synaptic membrane components are transient, whereas memories can endure. This suggests synaptic information is encoded and 'hard-wired' elsewhere, e.g. at molecular levels within the post-synaptic neuron. In long-term potentiation (LTP), a cellular and molecular model for memory, post-synaptic calcium ion (Ca 2+ ) flux activates the hexagonal Ca 2+ -calmodulin dependent kinase II (CaMKII), a
doi:10.1371/journal.pcbi.1002421
pmid:22412364
pmcid:PMC3297561
fatcat:snwxwrxfnrbg3chjzgou326vyi