Report of the Progress of Physiology

1872 BMJ (Clinical Research Edition)  
whole of the chioral is decomposed into chloroform and formic acid RE OR by the blcod, for, after it has been mixed with blood and warmed, the indications of the presence of chloroform are not increased by the ad-OF dition of sodium carbonate to the blood. The chloroform and formic acid are finally converted into sodium chloride and formiate, and elimini-THE PROGRESS OF PHYSIOLOGY. ated by the urine. The author believes the differences between the ________________~~~action of chloral and
more » ... chloral and chloroform to be due to the chloroform given off from chloral being in a nascent condition. Li cases of suppurative PHYSIOLOGICAL ACTION OF DRUGS. arthritis, white swelling, or necrosis, where chloral given by the mouth, Ah//y c~ourtion fter Poisoninj~l~y Phosj/owrus.-Voit and Bauer as well as subcutaneous injection of opium, have not afforded relief, the (Xeues Rcjpcrt. fr;~J'/zarm., xx, 340 ; and Zei/schz. filr Diol., vii, p. 63) author has seen much benefit derived from the local application of find that fatty degeneration of the organs is produced by phosphorus, chloral either to a sinus or endermically. H-e finds it useful in the even in animals deprived of food and extremely emaciated. The fat cough of measles and in whooping-coughi. It is of little use in epilepsy. cannot, therefore, come either from the food or from any other part of It is best given in syrup of tolu or syrup of oranges. The ordinary the body, and must be formed by the decomposition of albumen in the dose for an adult is two to three grammcs; for children under five years, organs themselves. The administration of phosphorus diminished both not more than 15 to 25 cenlig-;-anmcs; under ten years, 25 to 50 ceon/i' the oxygen taken in and the carbonic acid given off, buIiceaeItegr 'es ; between ten and fifteen years, one to two gr-anmes. Hypeurea excreted. This shows that the fatty degeneration which it produces dermic injections of one groole of chloral in one 5,-anmnc of water aire is due both to the oxidation of fat being diminished, and to its forma-useful in furious mania, delirium tremens, and tetanus. This method tion being increased by the transformation of albumen being quickened. of application has the inconvenience of producing local inflammation. The transformation of albumen is independent of the supply of oxygen. Chloral may be employed endermically by placing one grammi of it ini The oxygen taken in does not oxidise the albumen itself so much as the powder on a wound or fistulous opening, or on a blistered surface, about products of its decomposition; and when oxygen is deficient these pro-an inch in diameter. It produces a soft greyish slough, which falls ducts may accumulate in the body. They consider that leucine and off in two or three days, leaving a wound ready to receive a fresh dose. tyrosine are among the first products of the decomposition of albumen. The wound should be covered with lint or charpie to prevent the dis-Leucine is converted in the body into urea. They found much urea but solved chloral fl-em running over the adjacent skin and blistering it. no leucine or t)yrosine in the urine of dogs, but they found them in the Chloral is contraindicated by gastric irritation, by organic lesions of the
doi:10.1136/bmj.1.593.499 fatcat:vwmlospzdrh5niejokwcuky7va