The effect of lipoate on anaerobic cysteine metabolism in erythrocytes of patients treated with peritoneal dialysis

Małgorzata Iciek, Bernadeta Marcykiewicz, Anna Bilska-Wilkosz, Maria Sokołowska-Jeżewicz, Joanna Kłapcińska
2014 Pharmacological Reports  
A B S T R A C T Background: The studies aimed to evaluate the changes in cysteine sulfur metabolism in erythrocytes of end-stage renal failure (ESRF) patients treated with continuous ambulatory peritoneal dialysis (CAPD) caused by a one-month lipoate (LA) supplementation at a daily dose of 600 mg. Methods: The level of sulfane sulfur and activity of sulfurtransferases were determined in erythrocytes of CAPD patients and in the control group. Results: The sulfane sulfur level in erythrocytes of
more » ... in erythrocytes of CAPD patients did not differ compared with healthy volunteers but LA supplementation increased the reactive sulfur concentration. LA elevated also cystathionase activity. Conclusions: LA supplementation in ESRF patients treated with CAPD increases the sulfane sulfur level which indicates the augmentation of its antioxidant and regulatory properties.
doi:10.1016/j.pharep.2013.09.011 pmid:24911088 fatcat:gqgfvlbxpbd6rkiebyd3ujt6i4