Early complicated schistosomiasis in a returning traveller: Key contribution of new molecular diagnostic methods

Simon Bonnefond, Lieselotte Cnops, Alexandre Duvignaud, Emmanuel Bottieau, Thierry Pistone, Jan Clerinx, Denis Malvy
2019 International Journal of Infectious Diseases  
Early schistosomiasis poses a serious diagnostic challenge, because current standard diagnostic techniques based on serology and egg microscopy lack sensitivity at the initial presentation. We report spinal cord neuroschistosomiasis in a traveller developing 6 weeks after exposure. The diagnosis was confirmed by Schistosoma mansoni-targeted real-time PCR in blood and cerebrospinal fluid, before the results of conventional methods became positive. Molecular assays represent a paradigm shift for
more » ... he difficult diagnosis of early schistosomiasis and related complications.
doi:10.1016/j.ijid.2018.11.018 fatcat:ayku45jch5gp3jtu3gsbzsumpa