Consistent Re-Modeling of Signaling Pathways and Its Implementation in the TRANSPATH Database

Claudia Cho, Torsten Crass, Alexander Kel, Olga Kel-Margoulis, Mathias Krull, Susanne Pistor, Anatolij Potapov, Nico Voss, Edgar Wingender
2004 Genome Informatics Series  
The data model of the signaling pathways database TRANSPATH has been re-engineered to a three-layer model comprising experimental evidences and summarized pathway information, both in a mechanistically detailed manner, and a "semantic" projection for the abstract overview. Each molecule is described in the context of a certain reaction in the multidimensional space of posttranslational modification, molecular family relationships, and the biological species of its origin. The new model makes
more » ... data better suitable for reconstructing signaling pathways and networks and mapping expression data, for instance from microarray experiments, onto regulatory networks.
doi:10.11234/gi1990.15.2_244 fatcat:urw3dchqtfe7nogvwwiwh2vtzm