Jaundice is a common health issue especially in pediatric practice. It can be physiological or pathological hence has supreme importance clinically. Aim: To determine the accuracy of cord blood alkaline phosphatase levels for predicting neonatal hyperbilirubinemia. Study Design: Descriptive case series. Methodology: It was conducted at Department of Pediatrics, Sir Ganga Ram Hospital-Lahore. All neonates fulfilling the inclusion criteria were enrolled. Their demographic information, gestational

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... and birth history was taken. Cord blood sample (5ml) was taken and measured for ALP level and total bilirubin level. Statistical analysis: Data analyzed by using SPSS 23. Chi-square was applied. Results: Predictive accuracy of cord blood ALP level for predicting neonatal hyper-bilirubinemia showing sensitivity and specificity as 91.60% and 93.04 respectively. Conclusion: It was concluded that predictive accuracy of cord blood alkaline phosphatase level is good and reliable for predicting neonatal hyperbilirubinemia. Keywords: Neonatal Hyper-bilirubinemia, Cord Blood Alkaline Phosphatase and Predictive Accuracy.