Distinct Reactivity of Pd(OTs) 2 : The Intermolecular Pd(II)-Catalyzed 1,2-Carboamination of Dienes

Chris D. Bailey, Michel R. Gagné, Kevin I. Booker-Milburn, Chris E. Houlden, J. Gair Ford, Guy C. Lloyd-Jones
A Pd-catalyzed intermolecular 1,2-carboamination route to indolines from N-aryl ureas and 1,3-dienes that proceeds under mild conditions in relatively nonacidic media, is presented. The in situ generation, or preformation, of a palladium tosylate emerges as a key parameter in gaining the requisite reactivity for the C-H insertion/carbopalladation/nucleophilic displacement process.
doi:10.17615/yvd8-s387 fatcat:do3m4cokdncg3adsvvhm7jtmja