Cortical depth-dependent human fMRI of resting-state networks using EPIK [article]

Patricia Pais-Roldan, Seong Dae Yun, Nicola Palomero-Gallagher, Jon N Shah
2020 bioRxiv   pre-print
Recent laminar-fMRI studies have provided substantial understanding of the evoked cortical responses in multiple sub-systems; in contrast, the laminar component of resting-state networks remains largely unknown. Here, we used EPIK, which offers unprecedented coverage at sub-millimetre resolution, to investigate cortical resting-state dynamics with depth specificity. After verifying laminar activation profiles in response to a task, we investigated whole-brain laminar dynamics. During rest,
more » ... l oscillations were stronger in the superficial layers of the cortical ribbon, and functional connectivity analysis indicated that most resting-state cortical connections occurring at rest involve supra-granular layers. Coherence assessed in a lateral motor network suggested a modified distribution of layer-specific responses during task performance compared to resting-state. Whole-brain evaluation of laminar-fMRI encompasses unprecedented computational challenges; nonetheless, it enables a new dimension of the human cerebral cortex to be investigated from a global view, which may be key in the characterization of neurological disorders from a novel perspective.
doi:10.1101/2020.12.07.414144 fatcat:rpglxr5lb5b7povddk7i7fxiay