Multi-Link Vision stent vs. first-generation drug-eluting stents: systematic review and meta-analysis

L. Testa, R. A. Latini, S. Pizzocri, S. Lanotte, M. Agnifili, M. L. Laudisa, N. Brambilla, F. Bedogni
2011 QJM: Quarterly journal of medicine  
TVR. Risk of ST was 0.5%. Compared to first generation of DES in RCTs, at a mean follow-up of 10.5 months, MLV achieved similar results in terms of MAE, death and MI. On the other hand, MLV was associated with a double risk of TVR [OR 2.01 (1.34-3.01), P < 0.001, number needed to treat 18 (13-40)]. Overall, in stent late loss with MLV was 0.81 mm (AE0.51), while the in segment late loss was 0.61 mm (AE0.5). Risk of stent thrombosis was equivalent. Of note, performance of MLV in terms of safety,
more » ... efficacy and risk of repeat revascularization was quite consistent across all the published studies, despite inherent differences in study design, clinical setting, complexity of the lesions and ethnicity. Conclusion: Compared to first-generation DES, MLV showed substantial equivalence with respect to hard clinical endpoints. Data are consistent in study registries and RCTs meaning that the overall performance of MLV is quite predictable and reproducible into the wide spectrum of clinical settings.
doi:10.1093/qjmed/hcr138 pmid:21896624 fatcat:sy3wwn5trnexdcf7wpjo7heqjm