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Nuclear speckle-localized RNAs exhibit preferential positioning and orientation
AbstractNuclear speckles are a type of membraneless organelle in higher eukaryotic nuclei. Multivalent interactions between residing proteins and RNAs not only drive the formation, but also the layered compositional organization of nuclear speckles. Here, using super-resolution imaging, we demonstrate that nuclear speckle-localized RNA transcripts exhibit preferential intra-speckle positioning and radial orientation. Specifically, we show that transcripts containing a region enriched in SRdoi:10.1101/2022.10.17.512423 fatcat:osudddru6vfqdn3bqbqutlorta