Objective: To explore the effect of bundle care on the incidence of venous thromboembolism (VTE) in patients who received renal biopsy, and provide reference for clinical care. Methods: 300 patients with nephrotic syndrome who received renal biopsy in our hospital from February 2018 to August 2020 were selected and randomly divided into the observation group and the control group, with 150 patients in each group. In the control group, patients were given routine care: informing the precautions

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... efore and after operation, observing the changes of vital signs and bleeding after operation, etc. In the observation group, patients were given bundle care intervention, including preoperative, intraoperative and postoperative routine care, ankle pump exercise, Intermittent Pneumatic Compression (IPC) treatment and psychological care. The incidence of lower-limb venous thrombosis was compared between the two groups. Results: The incidence of deep venous thrombosis in the observation group was lower than that in the control group (P < 0.05), 1 case (0.6%) in the observation group and 8 cases (5.3%) in the control group; the peak velocity and mean velocity of lower-limb venous blood flow in the observation group were higher than those in the control group; the average length of stay in the observation group was less than that in the control group, and the satisfaction degree in the observation group was higher than that in the control group. The differences were statistically significant (P < 0.05). Conclusion: For patients who received renal biopsy, bundle care can help improve the peak velocity and mean velocity of venous blood flow, reduce the incidence of VTE, the average length of stay, and social costs, relieve their pain, and improve satisfaction degree of care; moreover, it plays an important role in reducing the incidence of deep venous thrombosis.