Can we develop a Canadian Perioperative Anesthesiology Clinical Trials Group?
Canadian Journal of Anesthesia
The development of a collaborative research network in Canada: what is PACT? In Canada, research in the field of anesthesiology has been restricted mainly to the domains of basic science and applied physiology. Despite being of valuable scientific relevance and importance, most of this research evaluates physiologic outcomes or surrogate clinical outcomes rather than clinically significant outcomes that could change the way in which we practice. While many medical specialties have appreciated
... e importance of evaluating outcomes, such as mortality, quality of life, length of stay or efficiency of care, anesthesiology has lagged behind. One of the main reasons Canadian anesthesiology has been slow to embrace outcome studies is the delayed development of a collaborative network of anesthesia investigators to advance multicentre clinical research projects. Clinical research is at a turning point and is rapidly evolving, not only in Canada but worldwide. We strongly believe that Canadian anesthesiologists are capable of markedly improving their research capacity by fostering collaborative outcome-driven research. We further believe that such research can and will change clinical practice. In order to attain this goal, we have initiated a collaborative research network, the Perioperative Anesthesiology Clinical Trials (PACT) group. The PACT group is a collaborative group of Canadian academic anesthesiologists with an interest in the design, implementation, conduct, and publication of multicentre clinical trials in anesthesiology and perioperative medicine. The aim of the PACT initiative is to help anesthesiology clinician investigators 1) to identify and investigate clinically relevant questions in anesthesiology and perioperative medicine; 2) to build research programs that answer their research questions; 3) to structure and conduct quality research with sound methodology; 4) to facilitate collaboration amongst various investigators across Canada so as to conduct multicentre research; 5) to acquire peer-reviewed funding from granting agencies; and finally 6) to execute and publish their results in high-impact peer-reviewed journals. The primary focus of the PACT initiative is to generate knowledge in perioperative anesthesia by providing a forum for the development and implementation of multicentre clinical trials that are designed to answer research questions. It is anticipated that the forum will have a fundamental impact on the practice of anesthesiology and perioperative medicine. In addition, the PACT group will provide mentoring to new investigators as a collaborative network and will facilitate the dissemination of research knowledge, best practices, and standardization of practice parameters, thereby informing the practice of anesthesiology and ensuring its continued advancement as a profession.